[CK] [ ] IM NARLOXONE 1MG IVP(0.4 - 2MG) REPEATING 2-3MINUTES (UPTO 10MG, MAY REPEAT 20-60MINS AS WELL)
IV, IM, SubQ: Initial: 0.4 to 2 mg; may need to repeat doses every 2 to 3 minutes. A lower initial dose (0.1 to 0.2 mg) should be considered for patients with opioid dependence to avoid acute withdrawal or if there are concerns regarding concurrent stimulant overdose (Mokhlesi 2003). After reversal, may need to readminister dose(s) at a later interval (ie, 20 to 60 minutes) depending on type/duration of opioid. If no response is observed after 10 mg total, consider other causes of respiratory depression. PEAK: 15MINUTES HALF: 3 HOURS.
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